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How cells flex their PEX to fine-tune lipolysis in NAFLD

Lipolysis generates fatty acids that are burned in peroxisomes for energy, and dysregulation in this process creates toxic reactive oxygen species (ROS) and contributes to diseases such as non-alcoholic fatty liver disease. In this issue of Nature Metabolism, Ding et al. reveal how the peroxin PEX2 senses cellular ROS to fine-tune ATGL-mediated lipolysis.

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Fig. 1: Schematic of PEX2 regulation in ATGL-mediated lipolysis.

References

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Acknowledgements

The authors apologize for any references omitted owing to space constraints. This work was supported by funds from the Welch Foundation (I-1873), the NIH NIGMS (GM119768), NIDDK (DK126887) and the UTSW Endowed Scholars Program.

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Correspondence to W. Mike Henne.

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Paul, B., Henne, W.M. How cells flex their PEX to fine-tune lipolysis in NAFLD. Nat Metab 3, 1591–1593 (2021). https://doi.org/10.1038/s42255-021-00490-9

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