Immune cells can promote the thermogenic phenotype of white adipocytes during cold exposure, in a process known as ‘browning’ or ‘beiging’. Wang et al. now reveal a potential mechanism whereby alternatively activated macrophages prompt adipose sympathetic nerve fibres to release norepinephrine and promote adipocyte beiging.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Villarroya, F., Cereijo, R., Villarroya, J., Gavaldà-Navarro, A. & Giralt, M. Cell Metab. 27, 954–961 (2018).
Guilherme, A., Henriques, F., Bedard, A. H. & Czech, M. P. Nat. Rev. Endocrinol. 15, 207–225 (2019).
Chi, J. et al. Cell Metab. 27, 226–236.e3 (2018).
Jiang, H., Ding, X., Cao, Y., Wang, H. & Zeng, W. Cell Metab. 26, 686–692.e3 (2017).
Wang, Y. N. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00482-9 (2021).
Tong, M., Jun, T., Nie, Y., Hao, J. & Fan, D. J. Cancer 10, 2694–2705 (2019).
Gonda, Y., Namba, T. & Hanashima, C. Front. Cell Dev. Biol. 8, 607415 (2020).
Pirzgalska, R. M. et al. Nat. Med. 23, 1309–1318 (2017).
Camell, C. D. et al. Nature 550, 119–123 (2017).
Svensson, K. J. et al. Cell Metab. 23, 454–466 (2016).
Henriques, F. et al. Cell Rep. 32, 107998 (2020).
Acknowledgements
The author gratefully acknowledges excellent discussions on this topic with laboratory members and relevant funding from the US National Institute of Diabetes and Digestive and Kidney Diseases (grants DK030898 and DK116056).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Czech, M.P. Macrophage ROBOcalls rattle adipose nerves. Nat Metab 3, 1441–1442 (2021). https://doi.org/10.1038/s42255-021-00484-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-021-00484-7