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Glutamine gluttony of efferocytes

Nature Metabolism volume 3, pages 1280–1281 (2021)Cite this article

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Dysfunctional efferocytosis impairs clearance of apoptotic cells in disease. A new study shows that glutamine catabolism supports efficient apoptotic cell efferocytosis via non-canonical glutamine transamination but not canonical GLUD1-dependent α-ketoglutarate production, in a process that may operate in human atherosclerosis.

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Fig. 1: Reparative macrophages bypass the canonical glutamine metabolism pathway to potentiate efferocytosis.

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Author notes

  1. These authors contributed equally: Alison Jaccard, Xiaoyun Li.

Authors and Affiliations

  1. Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland

    Alison Jaccard, Xiaoyun Li & Ping-Chih Ho

  2. Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland

    Alison Jaccard, Xiaoyun Li & Ping-Chih Ho

Authors
  1. Alison Jaccard
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  2. Xiaoyun Li
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  3. Ping-Chih Ho
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Corresponding authors

Correspondence to Alison Jaccard or Ping-Chih Ho.

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The authors declare no competing interests.

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Jaccard, A., Li, X. & Ho, PC. Glutamine gluttony of efferocytes. Nat Metab 3, 1280–1281 (2021). https://doi.org/10.1038/s42255-021-00462-z

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