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CHRONOBIOLOGY

Liver zonation—a journey through space and time

Nature Metabolism volume 3, pages 7–8 (2021)Cite this article

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Liver function depends on the temporal and zonal distribution of complementary metabolic tasks in hepatocytes. A new study by Droin et al. highlights how chronobiology and liver zonation orchestrate liver metabolism at single-cell resolution.

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Fig. 1: Spatiotemporal distribution of hepatic gene expression.

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Authors and Affiliations

  1. Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

    Stefano Annunziato & Jan S. Tchorz

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  1. Stefano Annunziato
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  2. Jan S. Tchorz
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Correspondence to Jan S. Tchorz.

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The authors declare no competing interests.

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Annunziato, S., Tchorz, J.S. Liver zonation—a journey through space and time. Nat Metab 3, 7–8 (2021). https://doi.org/10.1038/s42255-020-00333-z

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