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STEM CELL DIFFERENTIATION

Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome

Nature Structural & Molecular Biology volume 27, pages 685–686 (2020)Cite this article

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Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.

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Fig. 1: Bivalent domains are established at Dppa2/4-bound promoters in ESCs.

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Authors and Affiliations

  1. Department of Genetics, the Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, Israel

    Patrick S. L. Lim & Eran Meshorer

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  1. Patrick S. L. Lim
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  2. Eran Meshorer
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Correspondence to Eran Meshorer.

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Lim, P.S.L., Meshorer, E. Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome. Nat Struct Mol Biol 27, 685–686 (2020). https://doi.org/10.1038/s41594-020-0453-1

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