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PARKINSON’S DISEASE

Parkinson’s disease in the single-cell era

Nature Neuroscience volume 25, pages 536–538 (2022)Cite this article

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Degeneration of dopaminergic neurons in the substantia nigra is a pathological hallmark of Parkinson’s disease (PD). However, not all dopamine-producing neurons degenerate. Kamath, Abdulraouf et al. find that there are ten transcriptionally defined dopaminergic subpopulations in the human substantia nigra, but only one carries significant PD genetic risk and is vulnerable to neurodegeneration in PD.

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Fig. 1: Scheme of the molecular anatomy of the human substantia nigra pars compacta.

References

  1. Dahlstrom, A. & Fuxe, K. Acta Physiol. Scand. Suppl. 232, 231–255 (1964).

    Google Scholar 

  2. Anden, N. E. et al. Life Sci. 3, 523–530 (1964).

    Article  CAS  Google Scholar 

  3. Poulin, J. F. et al. Cell Rep. 9, 930–943 (2014).

    Article  CAS  Google Scholar 

  4. Poulin, J. F., Gaertner, Z., Moreno-Ramos, O. A. & Awatramani, R. Trends Neurosci. 43, 155–169 (2020).

    Article  CAS  Google Scholar 

  5. La Manno, G. et al. Cell 167, 566–580.e19 (2016).

    Article  Google Scholar 

  6. Kamath, T. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01061-1 (2022).

    Article  PubMed  Google Scholar 

  7. Oosterveen, T. et al. Stem Cell Reports 16, 2718–2735 (2021).

    Article  CAS  Google Scholar 

  8. Panman, L. et al. Cell Rep. 8, 1018–1025 (2014).

    Article  CAS  Google Scholar 

  9. Inestrosa, N. C. & Arenas, E. Nat. Rev. Neurosci. 11, 77–86 (2010).

    Article  CAS  Google Scholar 

  10. Pereira Luppi, M. et al. Cell Rep. 37, 109975 (2021).

    Article  CAS  Google Scholar 

  11. Saito, S. et al. J. Hum. Genet. 48, 461–468 (2003).

    Article  CAS  Google Scholar 

  12. Reardon, K. A., Mendelsohn, F. A., Chai, S. Y. & Horne, M. K. Aust. N. Z. J. Med. 30, 48–53 (2000).

    Article  CAS  Google Scholar 

  13. Labandeira-García, J. L. et al. Front. Neuroanat. 8, 67 (2014).

    PubMed  PubMed Central  Google Scholar 

  14. Bryois, J. et al. Nat. Genet. 52, 482–493 (2020).

    Article  CAS  Google Scholar 

  15. Surmeier, D. J., Obeso, J. A. & Halliday, G. M. Nat. Rev. Neurosci. 18, 101–113 (2017).

    Article  CAS  Google Scholar 

Download references

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  1. Karolinska Institutet, MBB, Molecular Neurobiology, Stockholm, Sweden

    Ernest Arenas

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  1. Ernest Arenas
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Correspondence to Ernest Arenas.

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Arenas, E. Parkinson’s disease in the single-cell era. Nat Neurosci 25, 536–538 (2022). https://doi.org/10.1038/s41593-022-01069-7

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