Capturing cell organization in the tumor microenvironment using spatial proteomics can provide insight into the disease. A pair of studies applying this to advanced lung and brain tumors identifies organizational immune hallmarks that are associated with patient outcomes.
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M.A. and S.C.B. declare that they are founders and paid consultants for Ionpath, the commercial supplier of MIBI spatial proteomic technology. H.P. declares no competing interests.
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Piyadasa, H., Angelo, M. & Bendall, S.C. Spatial proteomics of tumor microenvironments reveal why location matters. Nat Immunol 24, 565–566 (2023). https://doi.org/10.1038/s41590-023-01471-8
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DOI: https://doi.org/10.1038/s41590-023-01471-8
