Single large-scale mitochondrial DNA deletions cause a spectrum of disease with differing severities and tissue expressivity. Quantification of single-cell deletion levels with multi-modal cellular readouts provides insights into hematopoietic cell fate and disease manifestation.
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Acknowledgements
This work was supported by the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z). SJP is a Wellcome Career Re-entry Fellow (204709/Z/16/Z), GH receives funding from Parkinson’s UK (G-2003 and G-2201) and the Michael J Fox Foundation (MJFF-007574) and LGC receives funding from Cancer Research UK (DRCPFA-Nov22/100001). For the purpose of open access, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.
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Pickett, S.J., Hudson, G. & Greaves, L.C. Single-cell multiomic analyses sheds light on mitochondrial mutational selection. Nat Genet 55, 1083–1085 (2023). https://doi.org/10.1038/s41588-023-01436-5
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DOI: https://doi.org/10.1038/s41588-023-01436-5
