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NEUROENDOCRINE CANCER

Combining radiolabelled therapies for neuroendocrine neoplasms

Neuroendocrine liver metastases often require multiple modes of treatment to attain disease control, which can utilize various forms of radiolabelled agents either delivered systemically or preferentially towards the liver. A recent trial suggested both safety and efficacy of a novel approach of combining the two to provide a radiation ‘boost’ to hepatic deposits.

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References

  1. Frilling, A. et al. Recommendations for management of patients with neuroendocrine liver metastases. Lancet Oncol. 15, e8–21 (2014).

    Article  Google Scholar 

  2. Dasari, A. et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 3, 1335–1342 (2017).

    Article  Google Scholar 

  3. Chen, J. X. et al. Embolotherapy for neuroendocrine tumor liver metastases: prognostic factors for hepatic progression-free survival and overall survival. Cardiovasc. Intervent. Radiol. 40, 69–80 (2017).

    Article  Google Scholar 

  4. Kratochwil, C. et al. Hepatic arterial infusion enhances DOTATOC radiopeptide therapy in patients with neuroendocrine liver metastases. Endocr. Relat. Cancer 18, 595–602 (2011).

    Article  CAS  Google Scholar 

  5. Kennedy, A. et al. Role of hepatic intra-arterial therapies in metastatic neuroendocrine tumours (NET): guidelines from the NET-Liver-Metastases Consensus Conference. HPB 17, 29–37 (2015).

    Article  Google Scholar 

  6. Frilling, A. et al. Radioembolisation with 90Y microspheres for neuroendocrine liver metastases: an institutional case series, systematic review and meta-analysis. HPB 21, 773–783 (2019).

    Article  Google Scholar 

  7. Braat, A. J. A. T. et al. Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study. Lancet Oncol. 21, 561–570 (2020).

    Article  CAS  Google Scholar 

  8. Strosberg, J. et al. Phase 3 Trial of 177Lu-dotatate for midgut neuroendocrine tumors. N. Engl. J. Med. 376, 125–135 (2017).

    Article  CAS  Google Scholar 

  9. Pavel, M. et al. ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN of unknown primary site. Neuroendocrinology 103, 172–185 (2016).

    Article  CAS  Google Scholar 

  10. Kennedy, A. et al. Safety of selective internal radiation therapy (SIRT) with yttrium-90 microspheres combined with systemic anticancer agents: Expert consensus. J. Gastrointest. Oncol. 8, 1079–1099 (2017).

    Article  Google Scholar 

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Correspondence to Andrea Frilling.

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A.F. reports receiving speaker honoraria from SIRTEX. A.K.C. declares no competing interests.

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Frilling, A., Clift, A.K. Combining radiolabelled therapies for neuroendocrine neoplasms. Nat Rev Endocrinol 16, 347–348 (2020). https://doi.org/10.1038/s41574-020-0367-3

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