Chimeric antigen receptor (CAR) T cells have remarkable efficacy in patients with B cell acute lymphoblastic leukaemia (ALL), but have not been successful to date in patients with T cell ALL (T-ALL). Now, data from Pan and colleagues demonstrate the safety and impressive short-term efficacy of allogeneic donor-derived anti-CD7 CAR T cells in an early-phase clinical trial involving patients with relapsed and/or refractory T-ALL.
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D.T.T. serves on the scientific advisory boards of BEAM Therapeutics, Janssen, La Roche and Sobi; receives research funding from Leukemia and Lymphoma Society and Neoimmune Tech; and has a patent pending on biomarkers for cytokine-release syndrome (US2018025272A1). S.P.H. owns stock in Amgen and has received honoraria for lectures from Amgen and Jazz.
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Teachey, D.T., Hunger, S.P. Anti-CD7 CAR T cells for T-ALL: impressive early-stage efficacy. Nat Rev Clin Oncol 18, 677–678 (2021). https://doi.org/10.1038/s41571-021-00556-3
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DOI: https://doi.org/10.1038/s41571-021-00556-3
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