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Human antibodies against DBP

Duffy-binding protein (DBP) is the leading vaccine candidate for Plasmodium vivax malaria. Two studies express and characterise the first human monoclonal antibodies against DBP, induced by natural infection and vaccination, showing they have in vitro functional activity but target different conserved epitopes.

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Fig. 1: Antigenic regions of DBP RII as identified by human and murine mAbs.

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Correspondence to Jack S. Richards.

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Richards, J.S., Ramsland, P.A. Human antibodies against DBP. Nat Microbiol 4, 1428–1429 (2019). https://doi.org/10.1038/s41564-019-0549-8

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