The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV functions. This Comment discusses the roles and biogenesis of the EV corona, as well as the importance of controls to determine whether a biological effect is attributable to the internal EV cargo or to the corona associated with the EV exofacial surface.
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The author is a member of the advisory board of Sphere Gene Therapeutics Inc. (Boston, USA).
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Buzas, E.I. Opportunities and challenges in studying the extracellular vesicle corona. Nat Cell Biol 24, 1322–1325 (2022). https://doi.org/10.1038/s41556-022-00983-z
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DOI: https://doi.org/10.1038/s41556-022-00983-z
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