In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein AIDA connects sympathetic input, reactive oxygen species, and uncoupling protein 1-mediated adaptive thermogenesis in BAT.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Becher, T. et al. Nat. Med. https://doi.org/10.1038/s41591-020-1126-7 (2021).
Betz, M. J. & Enerbäck, S. Nat. Rev. Endocrinol. 14, 77–87 (2018).
Zeng, W. et al. Cell 163, 84–94 (2015).
Shi, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00642-9 (2021).
Chouchani, E. T. et al. Nature 532, 112–116 (2016).
Luo, H. et al. Cell Metab. 27, 843–853.e6 (2018).
Feldmann, H. M., Golozoubova, V., Cannon, B. & Nedergaard, J. Cell Metab. 9, 203–209 (2009).
Kazak, L. et al. Proc. Natl Acad. Sci. USA 114, 7981–7986 (2017).
Chouchani, E. T., Kazak, L. & Spiegelman, B. M. Cell Metab. 29, 27–37 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Mills, E.L., Xiao, H. & Chouchani, E.T. AIDA and UCP1 snuggle up to prevent hypothermia. Nat Cell Biol 23, 216–218 (2021). https://doi.org/10.1038/s41556-021-00648-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-021-00648-3