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Retinoic-acid-induced osteogenesis of hiPSCs

Nature Biomedical Engineering volume 3, pages 504–506 (2019)Cite this article

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Retinoic acid induces the rapid osteogenic differentiation of patient-derived induced pluripotent stem cells, enabling the in vitro recapitulation of an osteogenesis imperfecta phenotype.

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Fig. 1: A streamlined protocol for the osteogenic differentiation of human iPSCs.
Fig. 2: hiPSC-derived osteogenic cultures generated ossified tissue in mice.

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Authors and Affiliations

  1. Divisions of Endocrinology and Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA

    Christina Jacobsen

  2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    Christina Jacobsen

  3. Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA, USA

    Christina Jacobsen & April M. Craft

  4. Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, USA

    April M. Craft

  5. Harvard Stem Cell Institute, Cambridge, MA, USA

    April M. Craft

Authors
  1. Christina Jacobsen
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  2. April M. Craft
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Correspondence to April M. Craft.

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Jacobsen, C., Craft, A.M. Retinoic-acid-induced osteogenesis of hiPSCs. Nat Biomed Eng 3, 504–506 (2019). https://doi.org/10.1038/s41551-019-0422-3

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