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Clinical nutrition

Ampelopsis grossedentata supplementation effectively ameliorates the glycemic control in patients with type 2 diabetes mellitus

European Journal of Clinical Nutrition volume 73, pages 776–782 (2019)Cite this article

Subjects

Abstract

Background

Some animal and cellular experiments showed that ampelopsis grossedentata (APL) was helpful to improve insulin resistance or glucose uptake.

Objective

The aim of this study was to assess the effects of APL on blood glucose metabolism, lipid, and renal function parameters in adults with type 2 diabetes mellitus (T2DM).

Methods

Eighty participants with T2DM were randomly assigned to the APL group (n = 40, 10 g of APL daily contained 970 mg of dihydromyricetin) or to the placebo group (n = 40, 10 g of APL daily deleted dihydromyricetin) for 1 month in a double-blind, randomized clinical trial. Blood levels of glucose and insulin, lipids, and renal function parameters were assayed.

Results

Seventy subjects completed the trial (36 in the APL group and 34 in the placebo group). The baseline characteristics were similar between the two groups. Compared with the placebo group, the levels of fasting plasma glucose, glycated albumin, cystatin C, and retinol binding protein-4 significantly decreased (all p < 0.05). Meanwhile, the levels of other lipids, apolipoproteins, and other parameters did not change.

Conclusions

One-month supplementation with APL obviously improved the glycemic control and parameters of renal function in adults with T2DM. Our findings suggested that a potential role for APL in the prevention and treatment of T2DM.

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Author Contributions

LR, YQ designed the research; LR, XLW, HDL, JX, JW, HL, MTM, and YQ conducted the research; LR, HDL, and JX analyzed the data; LR, XLW, and YQ performed statistical analysis and wrote the manuscript; YQ and MTM had primary responsibility for final content. All authors read and approved the final manuscript.

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Author notes

  1. These authors contributed equally: Li Ran, XiaoLan Wang

Authors and Affiliations

  1. Chongqing Medical Nutrition Research Center; Chongqing Key Laboratory of Nutrition and Food Safety; Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Army Medical University, Chongqing, China

    Li Ran, XiaoLan Wang, HeDong Lang, ManTian Mi & Yu Qin

  2. Department of Nutrition, XinQiao Hospital, Army Medical University, Chongqing, China

    Jing Xu, Jian Wang & Huan Liu

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  1. Li Ran
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Correspondence to Yu Qin.

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Ran, L., Wang, X., Lang, H. et al. Ampelopsis grossedentata supplementation effectively ameliorates the glycemic control in patients with type 2 diabetes mellitus. Eur J Clin Nutr 73, 776–782 (2019). https://doi.org/10.1038/s41430-018-0282-z

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