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Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities

Bone Marrow Transplantation volume 55, pages 496–504 (2020)Cite this article

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Hematopoietic cell transplantation (HCT) is in many cases the only curative approach to treat patients with hematologic malignant diseases. In addition, it is used to treat nonmalignant disorders including hemoglobinopathies, inborn errors of metabolism, immune deficiencies, autoimmune diseases, and some solid tumors [1]. HCT use continues to increase [2], but due to variables such as its cost and the availability of donors it is still performed mainly in high-income countries [3, 4]. However, developing regions such as Latin America are also seeing an expansion in its use [5, 6].

Latin America is composed of 28 countries and territories spanning more than 20 million km2. Close to 700 million, it represents 10% of the world’s population. In addition, ~60 million people of Hispanic/Latino American descent live in the United States. Both the Hispanic population in the United States and populations in Latin American countries are expected to continue growing, with mortality associated with cancer also expected to increase significantly in the coming decades [7]. These demographic variables suggest a scenario of increasing need for cancer treatment strategies including HCT in the region.

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Authors and Affiliations

  1. Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany

    Esteban Arrieta-Bolaños

  2. Brazilian Bone Marrow Registry (REDOME), Instituto Nacional do Câncer, Ministério da Saúde, Rio de Janeiro, RJ, Brazil

    Danielli Cristina Oliveira

  3. Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany

    Rodrigo Barquera

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Arrieta-Bolaños, E., Oliveira, D.C. & Barquera, R. Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities. Bone Marrow Transplant 55, 496–504 (2020). https://doi.org/10.1038/s41409-019-0737-4

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