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Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance

Prostate Cancer and Prostatic Diseases volume 21, pages 187–195 (2018)Cite this article

Subjects

Abstract

Background

Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current study examines this among men initially diagnosed with favorable-risk PCa and managed by active surveillance at Sunnybrook Health Sciences Centre in Canada and the Royal Marsden Hospital in the United Kingdom.

Methods

Participants completed a questionnaire on daily participation in non-leisure, transport, and recreational PA. A logistic regression was employed using PA as the independent variable and whether the patient reclassified to higher-risk PCa while on active surveillance as the dependent variable. Demographic and lifestyle covariates were incorporated in the analysis to assess potential confounding and effect modification.

Results

Men from both hospitals presented with similar clinical and demographic characteristics. Total PA was inversely associated with odds of reclassification while on active surveillance (p-trend = 0.027). A weaker inverse association was observed with recreational PA (p-trend = 0.30). Men who participated in weekly vigorous PA were less likely to reclassify than those who did not (odds ratio (95% confidence interval): 0.42 (0.20–0.85)).

Conclusions

Total and vigorous PA were inversely associated with odds of reclassification in two active surveillance cohorts. Given the limitations of this study, more robust prospective observational studies involving objective PA measures are warranted to confirm findings.

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Acknowledgements

Funding was not required or mobilized for this project. No additional personnel significantly contributed to this study other than the authors.

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Authors and Affiliations

  1. Schulich School of Medicine and Dentistry, Western University, Toronto, ON, Canada

    David E. Guy

  2. Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    David E. Guy, Avi Vandersluis, Laurence H. Klotz & Vasundara Venkateswaran

  3. Division of Urology, Department of Surgery, Princess Margaret Hospital, Toronto, ON, Canada

    Neil Fleshner

  4. Evaluative Clinical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Alexander Kiss

  5. Institute of Cancer Research, Royal Marsden Hospital, Sutton, UK

    Chris Parker

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  1. David E. Guy
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Correspondence to Vasundara Venkateswaran.

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Guy, D.E., Vandersluis, A., Klotz, L.H. et al. Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance. Prostate Cancer Prostatic Dis 21, 187–195 (2018). https://doi.org/10.1038/s41391-017-0010-0

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