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MET targeting: time for a rematch

Oncogene volume 39, pages 2845–2862 (2020)Cite this article

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Abstract

MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene involved in embryonic development and throughout life in homeostasis and tissue regeneration. Deregulation of MET signaling has been reported in numerous malignancies, prompting great interest in MET targeting for cancer therapy. The present review offers a summary of the biology of MET and its known functions in normal physiology and carcinogenesis, followed by an overview of the most relevant MET-targeting strategies and corresponding clinical trials, highlighting both past setbacks and promising future prospects. By placing their efforts on a more precise stratification strategy through the genetic analysis of tumors, modern trials such as the NCI-MATCH trial could revive the past enthusiasm for MET-targeted therapy.

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Fig. 1
Fig. 2: Summary of MET alterations frequency and outcome in different cancer types.

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Funding

This work has been supported by the Werner und Hedy Berger-Janser Stiftung (grant to MM).

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Authors and Affiliations

  1. Department for BioMedical Research, Inselspital, Bern University Hospital, and University of Bern, 3008, Bern, Switzerland

    Jonas P. Koch, Daniel M. Aebersold, Yitzhak Zimmer & Michaela Medová

  2. Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, 3010, Bern, Switzerland

    Jonas P. Koch, Daniel M. Aebersold, Yitzhak Zimmer & Michaela Medová

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  1. Jonas P. Koch
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  2. Daniel M. Aebersold
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  4. Michaela Medová
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Correspondence to Michaela Medová.

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Koch, J.P., Aebersold, D.M., Zimmer, Y. et al. MET targeting: time for a rematch. Oncogene 39, 2845–2862 (2020). https://doi.org/10.1038/s41388-020-1193-8

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  • DOI: https://doi.org/10.1038/s41388-020-1193-8

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