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Stem cell transplantation

Next-generation CD8 memory veto T cells directed against memory antigens

Leukemia volume 33, pages 2737–2741 (2019)Cite this article

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To the Editor,

Over the past decade, the use of mismatched haploidentical hematopoietic stem cell transplantation (haploSCT) has increasingly grown, as novel techniques that reduce the related complications of graft-rejection and graft-versus-host disease (GvHD) emerge for application of either T-cell replete or T-cell depleted (TCD) haploSCT [1]. T-cell replete grafts carry a substantial risk for GvHD even in the context of post-transplant cyclophosphamide (PTCY) and prolonged immunosuppression, while depleted grafts are associated with increased graft rejection.

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Author notes

  1. Noga Or-Geva

    Present address: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Interdepartmental Program in Immunology, Stanford, CA, USA

  2. Yair Reisner

    Present address: Department of Stem Cell Transplantation & Cellular Therapy, MD Anderson Cancer Center, Houston, TX, USA

  3. These author contributed equally: Noga Or-Geva, Rotem Gidron-Budovsky, Rakefet Sidlik-Muskatel

Authors and Affiliations

  1. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    Noga Or-Geva, Rotem Gidron-Budovsky, Rakefet Sidlik-Muskatel, Aloukick Kumar Singh & Yair Reisner

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  1. Noga Or-Geva
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Contributions

NOG, RGB, and RSM designed the research and performed the experiments, analyzed the results, and wrote the paper; AKS performed the experiments; YR designed the research, analyzed the results, and wrote the paper.

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Correspondence to Yair Reisner.

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YR is a shareholder and a consultant to Cell Source LTD. Remaining authors declare that they have no conflict of interest.

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Or-Geva, N., Gidron-Budovsky, R., Sidlik-Muskatel, R. et al. Next-generation CD8 memory veto T cells directed against memory antigens. Leukemia 33, 2737–2741 (2019). https://doi.org/10.1038/s41375-019-0501-1

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