Abstract
Whether it is nobler in the mind to suffer the slings and arrows of outrageous proliferation, or to take arms against stroma, and favor metastasis… This pastiche of Hamlet’s famous monologue illustrates recent reports on the paradoxical functions of well-established proliferation markers such as c-Myc or cyclin A2 that have revealed their ambiguous roles in the control of proliferation and metastasis. On the one hand, overexpression of c-Myc, while stimulating local proliferation, inhibits invasiveness of cancer cells, whereas on the other, downregulation of cyclin A2 leads to increased motility of transformed cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Arsic N, Bendris N, Peter M, Begon-Pescia C, Rebouissou C, Gadéa G et al. A novel function for cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol 2012; 196: 147–162.
Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G . Cyclin A is required at two points in the human cell cycle. EMBO J 1992; 11: 961–971.
Lindqvist A, Rodriguez-Bravo V, Medema R . The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol 2009; 185: 193–202.
Murphy M, Stinnakre MG, Senamaud-Beaufort C, Winston NJ, Sweeney C, Kubelka M et al. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet 1997; 15: 83–86.
Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I et al. Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 2009; 138: 352–365.
Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell MJ et al. MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol 2012; 14: 567–574.
Bissell MJM, Hines WC . Why don’t we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 2011; 17: 320–329.
Lu P, Weaver VM, Werb Z . The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol 2012; 196: 395–408.
Guo W, Giancotti FG . Integrin signaling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816–826.
Sahai E, Marshall CJ . ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol 2002; 4: 408–415.
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M . Beta 3 endonexin as a novel inhibitor of cyclin A-associated kinase. Biochem Biophys Res Commun 2000; 267: 947–952.
Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J . Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007; 104: 14694–14699.
Anastasiadis NZ, Moon SY, Thoreson MA, Mariner GJ, Crawford HC, Zheng Y et al. Inhibition of RhoA by p120 catenin. Nat Cell Biol 2000; 2: 637–644.
Acknowledgements
We thank Robert Hipskind and Daniel Fisher for their kind review of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no conflict of interest.
Rights and permissions
About this article
Cite this article
Blanchard, J. To be or not to be a proliferation marker?. Oncogene 33, 954–955 (2014). https://doi.org/10.1038/onc.2013.19
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/onc.2013.19
This article is cited by
-
Cyclin A2, a novel regulator of EMT
Cellular and Molecular Life Sciences (2014)