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One core, two shells: bacterial and eukaryotic ribosomes

Nature Structural & Molecular Biology volume 19, pages 560–567 (2012)Cite this article

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Abstract

Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to have evolved from a common ancestor by addition of proteins and RNA that bestow different functionalities to ribosomes from different domains of life. Recently, structures of the eukaryotic ribosome, determined by X-ray crystallography, have allowed us to compare these structures to previously determined structures of bacterial ribosomes. Here we describe selected bacteria- or eukaryote-specific structural features of the ribosome and discuss the functional implications of some of them.

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Figure 1: The translation cycle in bacteria and eukaryotes.
Figure 2: Composition of bacterial and eukaryotic ribosomes and the common core.
Figure 3: Bacteria- and eukaryote-specific proteins and RNA expansions of the small ribosomal subunit.
Figure 4: Bacteria- and eukaryote-specific proteins and RNA expansions of the large ribosomal subunit.
Figure 5: Distinctive features of the 80S ribosome structure.

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Acknowledgements

The authors apologize for not citing all relevant articles, owing to length restrictions. Work in the author's laboratory was supported by the Foundation for Medical Research Foundation in France, FRM (S.M.), a Molecular Biology Organization Long-Term Fellowship (A.B.-S.), Human Frontier Science Program, French National Research Agency grants ANR BLAN-07-3-190451 and ANR-0-PCVI-0015-01, and European Commission SPINE-2.

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Authors and Affiliations

  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France

    Sergey Melnikov, Adam Ben-Shem, Nicolas Garreau de Loubresse, Lasse Jenner, Gulnara Yusupova & Marat Yusupov

  2. Université de Strasbourg, Strasbourg, France

    Sergey Melnikov & Nicolas Garreau de Loubresse

  3. Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France

    Adam Ben-Shem & Lasse Jenner

  4. Centre National de la Recherche Scientifique, UMR7104, Illkirch, France.,

    Gulnara Yusupova & Marat Yusupov

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Correspondence to Marat Yusupov.

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Melnikov, S., Ben-Shem, A., Garreau de Loubresse, N. et al. One core, two shells: bacterial and eukaryotic ribosomes. Nat Struct Mol Biol 19, 560–567 (2012). https://doi.org/10.1038/nsmb.2313

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