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The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

Nature Structural Biology volume 4, pages 32–35 (1997)Cite this article

Transfection studies with cDNAs encoding hybrids between the highly similar cytochrome P450 enzymes, CYP11B1 (steroid 11β-hydroxylase) and CYP11B2 (aldosterone synthase) have identified which amino acids determine the different activities of the enzymes.

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Authors and Affiliations

  1. Collége de France, INSERM U36, 3 rue d'Ulm, 75005, Paris, France

    Kathleen M. Curnow, Paolo Mulatero, Pierre Corvol & Leigh Pascoe

  2. Baker Medical Research Institute, Box 348, Prahran, 3181, Australia

    Kathleen M. Curnow

  3. Service de Biochimie, CHU Pitié-Salpétrière, Université Paris VI, 91 bd de I' Hôpital, 75634, Paris, Cedex 13, France

    Nicole Emeric-Blanchouin & Brigitte Aupetit-Faisant

Authors
  1. Kathleen M. Curnow
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  5. Pierre Corvol
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  6. Leigh Pascoe
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Curnow, K., Mulatero, P., Emeric-Blanchouin, N. et al. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme. Nat Struct Mol Biol 4, 32–35 (1997). https://doi.org/10.1038/nsb0197-32

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