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SLE in 2011

Deciphering the role of NETs and networks in SLE

Nature Reviews Rheumatology volume 8, pages 68–70 (2012)Cite this article

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From neutrophil extracellular traps to genetic networks that underlie the disease and new targeted therapies, important advances in 2011 improve our understanding of the pathogenesis of systemic lupus erythematosus and mark the beginning of our ability to treat it effectively.

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Figure 1: From NETs to disease networks in SLE.

References

  1. Craft, J. Dissecting the immune cell mayhem that drives lupus pathogenesis. Sci. Transl. Med. 3, 73ps9 (2011).

    Article  Google Scholar 

  2. Rubtsov, A. V. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity. Blood 118, 1305–1315 (2011).

    Article  CAS  Google Scholar 

  3. Leadbetter, E. A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603–607 (2002).

    Article  CAS  Google Scholar 

  4. Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532–1535 (2004).

    Article  CAS  Google Scholar 

  5. Lande, R. et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci. Transl. Med. 3, 73ra19 (2011).

    Article  Google Scholar 

  6. Dörner, T., Giesecke, C. & Lipsky, P. E. Mechanisms of B cell autoimmunity in SLE. Arthritis Res. Ther. 13, 243 (2011).

    Article  Google Scholar 

  7. Taylor, K. E. et al. Risk alleles for systemic lupus erythematosus in a large case–control collection and associations with clinical subphenotypes. PLoS Genetics 7, e1001311 (2011).

    Article  CAS  Google Scholar 

  8. Lindh, E. et al. AIRE regulates T-cell-independent B-cell responses through BAFF. Proc. Natl Acad. Sci. USA 105, 18466–18471 (2008).

    Article  CAS  Google Scholar 

  9. Navarra, S. V. et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377, 721–731 (2011).

    Article  CAS  Google Scholar 

  10. Wallace, D. J. et al. A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum. 61, 1168–1178 (2009).

    Article  CAS  Google Scholar 

Download references

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  1. Department of Medicine, Rheumatology and Clinical Immunology, Charite Center 12, Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum, Chariteplatz 01, Berlin, 10098, Germany

    Thomas Dörner

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  1. Thomas Dörner
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Dörner, T. Deciphering the role of NETs and networks in SLE. Nat Rev Rheumatol 8, 68–70 (2012). https://doi.org/10.1038/nrrheum.2011.200

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