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Cerebrovascular disease

CeAD and migraine — an association built on shifting sands

A growing body of evidence indicates that people with migraine have an increased risk of cervical artery dissection (CeAD). A new study in young patients with ischaemic stroke has identified a specific link between CeAD and migraine without aura.

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References

  1. De Giuli, V. et al. Association between migraine and cervical artery dissection: the Italian Project on Stroke in Young Adults. JAMA Neurol. http://dx.doi.org/10.1001/jamaneurol.2016.5704 (2017).

  2. Metso, T. M. et al. Migraine in cervical artery dissection and ischemic stroke patients. Neurology 78, 1221–1228 (2012).

    Article  CAS  Google Scholar 

  3. Hu, X., Zhou, Y., Zhao, H. & Peng, C. Migraine and the risk of stroke: an updated meta-analysis of prospective cohort studies. Neurol. Sci. 38, 33–40 (2017).

    Article  Google Scholar 

  4. Rist, P. M. et al. Migraine, migraine aura, and cervical artery dissection: a systematic review and meta-analysis. Cephalalgia 31, 886–896 (2011).

    Article  Google Scholar 

  5. Engelter, S. T., Traenka, C., Von Hessling, A. & Lyrer, P. A. Diagnosis and treatment of cervical artery dissection. Neurol. Clin. 33, 421–441 (2015).

    Article  Google Scholar 

  6. Puledda, F. et al. A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers–Danlos syndrome, hypermobility type. Neurol. Sci. 36, 1417–1424 (2015).

    Article  Google Scholar 

  7. Henderson, F. C. Sr et al. Neurological and spinal manifestations of the Ehlers–Danlos syndromes. Am. J. Med. Genet. C Semin. Med. Genet. 175, 195–211 (2017).

    Article  Google Scholar 

  8. Freilinger, T. et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat. Genet. 44, 777–782 (2012).

    Article  CAS  Google Scholar 

  9. Debette, S. et al. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Nat. Genet. 47, 78–83 (2015).

    Article  CAS  Google Scholar 

  10. Grond-Ginsbach, C. et al. Spontaneous arterial dissection: phenotype and molecular pathogenesis. Cell. Mol. Life Sci. 67, 1799–1815 (2010).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Caspar Grond-Ginsbach.

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Grond-Ginsbach, C., Kloss, M. CeAD and migraine — an association built on shifting sands. Nat Rev Neurol 13, 261–262 (2017). https://doi.org/10.1038/nrneurol.2017.55

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