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Gut microbiota — at the intersection of everything?

Nature Reviews Gastroenterology & Hepatology volume 14, pages 321–322 (2017)Cite this article

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Abstract

Over the past decade, numerous studies have found an association between the gut microbiota composition and many diseases. However, is it reality? Or is the truth hidden in the shadow of several thousand publications a year with inflated expectations in almost any disease?

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Figure 1: Gut microorganisms at the intersection of several diseases.

References

  1. Sender, R., Fuchs, S. & Milo, R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164, 337–340 (2016).

    Article  CAS  Google Scholar 

  2. Thaiss, C. A. et al. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell 167, 1495–1510.e12 (2016).

    Article  CAS  Google Scholar 

  3. Brown, J. M. & Hazen, S. L. The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu. Rev. Med. 66, 343–359 (2015).

    Article  CAS  Google Scholar 

  4. Plovier, H. et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat. Med. 23, 107–113 (2017).

    Article  CAS  Google Scholar 

  5. Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022–1023 (2006).

    Article  CAS  Google Scholar 

  6. Cani, P. D. & Everard, A. Talking microbes: when gut bacteria interact with diet and host organs. Mol. Nutr. Food Res. 60, 58–66 (2016).

    Article  CAS  Google Scholar 

  7. Skyler, J. S. et al. Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes 66, 241–255 (2017).

    Article  CAS  Google Scholar 

  8. [No authors listed.] Standards of medical care in diabetes — 2017: summary of revisions. Diabetes Care 40, S4–S5 (2017).

  9. Hanage, W. P. Microbiology: microbiome science needs a healthy dose of scepticism. Nature 512, 247–248 (2014).

    Article  CAS  Google Scholar 

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Acknowledgements

P.D.C. is a research associate at FRS-FNRS (Fonds de la Recherche Scientifique) and the recipient of grants from FNRS (convention J.0084.15, convention 3.4579.11), PDR (Projet de Recherche, convention: T.0138.14) and Walloon region DG06-FSO project (Microbes 1510053). His work is supported by the FRFS-WELBIO under grant: WELBIO-CR-2012S-02R, and, in part, by the Funds Baillet Latour (Grant for Medical Research 2015). P.D.C. is a recipient of POC ERC grant 2016 (European Research Council, Microbes4U_713547) and ERC Starting Grant 2013 (Starting grant 336452-ENIGMO).

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  1. Université catholique de Louvain, Louvain Drug Research Institute, WELBIO (Walloon Excellence in Life sciences and BIOtechnology), Metabolism and Nutrition research group, Avenue E. Mounier, 73 box B1.73.11, Brussels, B-1200, Belgium

    Patrice D. Cani

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Correspondence to Patrice D. Cani.

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Cani, P. Gut microbiota — at the intersection of everything?. Nat Rev Gastroenterol Hepatol 14, 321–322 (2017). https://doi.org/10.1038/nrgastro.2017.54

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