Nonalcoholic fatty liver disease has long been neglected by health-care professionals unless affected patients develop cirrhosis; however, new research shows this disease impairs health-related quality of life. The association of nonalcoholic fatty liver disease with chronic metabolic diseases and cardiovascular complications restricts our ability to define a specific role for liver damage in the poor perceived health status of these patients.
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References
Ekstedt, M. et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44, 865–873 (2006).
Marchesini, G. et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37, 917–923 (2003).
David, K. et al. Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network. Hepatology 49, 1904–1912 (2009).
Ware, J. E. Jr, Snow, K., Kosinski, M. & Gandek, B. SF-36 Health Survey Manual and Interpretation Guide (New England Medical Center, Boston, 1993).
Corica, F. et al. Construct validity of the Short Form-36 Health Survey and its relationship with BMI in obese outpatients. Obesity (Silver Spring) 14, 1429–1437 (2006).
Anderson, R. M., Fitzgerald, J. T., Wisdom, K., Davis, W. K. & Hiss, R. G. A comparison of global versus disease-specific quality-of-life measures in patients with NIDDM. Diabetes Care 20, 299–305 (1997).
Marchesini, G. et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology 120, 170–178 (2001).
Helbling, B. et al. Host- rather than virus-related factors reduce health-related quality of life in hepatitis C virus infection. Gut 57, 1597–1603 (2008).
Newton, J. L. et al. Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut 57, 807–813 (2008).
Dan, A. A. et al. Health-related quality of life in patients with non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 26, 815–820 (2007).
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Marchesini, G., Bianchi, G. Disease and comorbidity—effects on quality of life. Nat Rev Gastroenterol Hepatol 6, 504–506 (2009). https://doi.org/10.1038/nrgastro.2009.142
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DOI: https://doi.org/10.1038/nrgastro.2009.142
