Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Celiac disease

Diagnosis criteria in young children

Diagnosis of celiac disease in children under 2 years of age at first biopsy currently requires a small-bowel biopsy to be taken after a gluten challenge. The authors of a new study question these recommendations, and suggest that gluten challenge and biopsy are not required in this group of patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Di Sabatino, A. & Corazza, G. R. Coeliac disease. Lancet 373, 1480–1493 (2009).

    Article  Google Scholar 

  2. Meeuwisse, G. W. Diagnostic criteria in coeliac disease. Acta Paediatr. Scand. 59, 461–463 (1970).

    Article  Google Scholar 

  3. Walker-Smith, J. A., Guandalini, S., Schmitz, J., Shmerling, D. H. & Visakorpi, J. K. Revised criteria for diagnosis of coeliac disease. Arch. Dis. Child. 65, 909–911 (1990).

    Article  Google Scholar 

  4. Danielsson, L., Stenhammar, L. & Åström, E. Is gluten challenge necessary for the diagnosis of coeliac disease in young children? Scand. J. Gastroenterol. 25, 957–960 (1990).

    Article  CAS  Google Scholar 

  5. Shmerling, D. H. & Franckx, J. Childhood celiac disease: a long-term analysis of relapses in 91 patients. J. Pediatr. Gastroenterol. Nutr. 5, 565–569 (1986).

    Article  CAS  Google Scholar 

  6. Stenhammar, L. et al. How do Swedish paediatric clinics diagnose coeliac disease? Results of a nationwide questionnaire study. Acta Paediatr. 95, 1495–1497 (2006).

    Article  Google Scholar 

  7. Wolters, V. M. et al. Is gluten challenge really necessary for the diagnosis of coeliac disease in children younger than age 2 years? J. Pediatr. Gastroenterol. Nutr. 48, 566–579 (2009).

    Article  CAS  Google Scholar 

  8. Högberg, L., Stenhammar, L. & Wågermark, J. Very late mucosal relapse in a girl with coeliac disease. Acta Paediatr. 82, 887–889 (1993).

    Article  Google Scholar 

  9. Fasano, A. et al. Federation of international societies of pediatric gastroenterology, hepatology, and nutrition consensus report on celiac disease. J. Pediatr. Gastroenterol. Nutr. 47, 214–219 (2008).

    Article  CAS  Google Scholar 

  10. Dickson, B. C., Streutker, C. J. & Chetty, R. Coeliac disease: an update for pathologists. J. Clin. Pathol. 59, 1008–1016 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lars Stenhammar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Högberg, L., Stenhammar, L. Diagnosis criteria in young children. Nat Rev Gastroenterol Hepatol 6, 447–448 (2009). https://doi.org/10.1038/nrgastro.2009.111

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2009.111

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing