Abstract
Retapamulin (Altabax; GlaxoSmithKline) is the first in a new class of antibacterial drugs known as pleuromutilins to be approved for use in humans. It was approved by the US FDA for the topical treatment of impetigo, a skin infection caused by bacteria, in April 2007, and approved in Europe (where it will be marketed as Altargo) for the treatment of impetigo and infected small lacerations, abrasions or sutured wounds in June 2007.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cole, C. & Gazewood, J. Diagnosis and treatment of impetigo. Am. Fam. Physician 75, 859–864 (2007).
Kavanagh, F., Hervey, A. & Robbins, W. J. Antibiotic substances from Basidiomycetes: VIII. Pleurotus Multilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat. Proc. Natl Acad. Sci. USA 37, 570–574 (1951).
Hunt, E. Pleuromutilin antibiotics. Drugs Future 25, 1163–1168 (2000).
Jones, R. N. et al. Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant Gram-positive cocci. Antimicrob. Agents Chemother. 50, 2583–2586 (2006).
Rittenhouse, S. et al. Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrob. Agents Chemother. 50, 3882–3885 (2006).
Food and Drug Administration. FDA labelling information [online], (2007).
Yan, K. et al. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob. Agents Chemother. 50, 3875–3881 (2006).
Davidovich, C. et al. Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity. Proc. Natl Acad. Sci. USA 104, 4291–4296 (2007).
Kosowska-Shick K. et al. Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes. Antimicrob. Agents Chemother. 50, 765–769 (2006).
Rittenhouse, S. et al. Use of the surgical wound infection model to determine the efficacious dosing regimen of retapamulin, a novel topical antibiotic. Antimicrob. Agents Chemother. 50, 3886–3888 (2006).
European Medicines Agency. European Public Assessment Report [online], (2007).
Daum, R. S. Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N. Engl. J. Med. 357, 380–390 (2007).
Han, L. L. et al. High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center. J. Clin. Microbiol. 45, 1350–1352 (2007).
Diep, B. A. et al. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 367, 731–739 (2006).
Gentry, D. R. et al. Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin. Antimicrob. Agents Chemother. 51, 2048–2052 (2007).
Jones, R. N. et al. Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia. Diagn. Microbiol. Infect. Dis. 54, 63–71 (2006).
IMS Health. IMS MIDAS Quantum (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Daum, R., Kar, S. & Kirkpatrick, P. Retapamulin. Nat Rev Drug Discov 6, 865–866 (2007). https://doi.org/10.1038/nrd2442
Issue Date:
DOI: https://doi.org/10.1038/nrd2442
This article is cited by
-
Total synthesis of structurally diverse pleuromutilin antibiotics
Nature Chemistry (2022)
-
Functional molecules from natural sources: Organized by the Royal Society of Chemistry Biotechnology Group, Magdalen College, Oxford, UK, 6–8 July 2009
The Journal of Antibiotics (2009)