Abstract
We recorded from parietal neurons in monkeys (Macacca mulatta) trained to report the direction of an apparent motion stimulus consisting of regularly spaced columns of dots surrounded by an aperture. Displacing the dots by half their inter-column spacing produced vivid apparent motion that could be perceived in either the preferred or anti-preferred direction for each neuron. Many neurons in the lateral intraparietal area (LIP) responded more strongly on trials in which the animals reported perceiving the neurons' preferred direction, independent of the hand movement used to report their percept. This selectivity was less common in the medial superior temporal area (MST) and virtually absent in the middle temporal area (MT). Variations in activity of LIP and MST neurons just before motion onset were also predictive of the animals' subsequent perceived direction. These data suggest a hierarchy of representation in parietal cortex, whereby neuronal responses become more aligned with subjective perception in higher parietal areas.
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References
Parker, A.J. & Newsome, W.T. Sense and the single neuron: probing the physiology of perception. Annu. Rev. Neurosci. 21, 227–277 (1998).
Albright, T.D. Cortical processing of visual motion. Rev. Oculomot. Res. 51, 77–201 (1993).
Andersen, R.A. Neural mechanisms of visual motion perception in primates. Neuron 18, 865–872 (1997).
Newsome, W.T., Britten, K.H. & Movshon, J.A. Neuronal correlates of a perceptual decision. Nature 341, 52–54 (1989).
Salzman, C.D., Murasugi, C.M., Britten, K.H. & Newsome, W.T. Microstimulation in visual area MT: effects on direction discrimination performance. J. Neurosci. 12, 2331–2355 (1992).
Britten, K.H., Newsome, W.T., Shadlen. M.N., Celebrini, S. & Movshon, J.A. A relationship between behavioral choice and the visual responses of neurons in macaque MT. Vis. Neurosci. 13, 87–100 (1996).
Leopold, D.A. & Logothetis, N.K. Multistable phenomena: changing views in perception. Trends Cogn. Sci. 3, 254–264 (1999).
Logothetis, N.K. & Schall, J.D. Neuronal correlates of subjective visual perception. Science 245, 761–763 (1989).
Bradley, D.C., Chang, G.C. & Andersen, R.A. Encoding of three-dimensional structure-from-motion by primate area MT neurons. Nature 392, 14–17 (1998).
Dodd, J.V., Krug, K., Cumming, B.G. & Parker, A.J. Perceptually bistable three-dimensional figures evoke high choice probabilities in cortical area MT. J. Neurosci. 21, 4809–4821 (2001).
Eskandar, E.N. & Assad, J.A. Distinct nature of directional signals among parietal cortical areas during visual guidance. J. Neurophysiol. 88, 1777–1790 (2002).
Eskandar, E.N. & Assad, J.A. Dissociation of visual, motor and predictive signals in parietal cortex during visual guidance. Nat. Neurosci. 2, 88–93 (1999).
Watanabe, T. & Cole, R. Propagation of local motion correspondence. Vision Res. 35, 2853–2861 (1995).
Bair, W. & O'Keefe, L.P. The influence of fixational eye movements on the response of neurons in area MT of the macaque. Vis. Neurosci. 15, 779–786 (1998).
Barash, S., Bracewell, R.M., Fogassi, L., Gnadt, J.W. & Andersen, R.A. Saccade-related activity in the lateral intraparietal area. II. Spatial properties. J. Neurophysiol. 66, 1109–1124 (1991).
Verstraten, F.A., Cavanagh, P. & Labianca, A.T. Limits of attentive tracking reveal temporal properties of attention. Vision Res. 40, 3651–3664 (2000).
Mikami, A., Newsome, W.T. & Wurtz, R.H. Motion selectivity in macaque visual cortex. II. Spatiotemporal range of directional interactions in MT and V1. J. Neurophysiol. 55, 1328–1339 (1986).
Livingstone, M.S., Pack, C.C. & Born, R.T. Two-dimensional substructure of MT receptive fields. Neuron 30, 781–793 (2001).
Felleman, D.J. & Van Essen, D.C. Distributed hierarchical processing in the primate cerebral cortex. Cereb. Cortex 1, 1–47 (1991).
Celebrini, S. & Newsome, W.T. Neuronal and psychophysical sensitivity to motion signals in extrastriate area MST of the macaque monkey. J. Neurosci. 14, 4109–4124 (1994).
Sheinberg, D.L. & Logothetis, N.K. The role of temporal cortical areas in perceptual organization. Proc. Natl. Acad. Sci. USA 94, 3408–3413 (1997).
Leopold, D.A. & Logothetis, N.K. Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry. Nature 379, 549–553 (1996).
Cavanagh, P. Attention-based motion perception. Science 257, 1563–1565 (1992).
Treue, S. & Maunsell, J.H. Effects of attention on the processing of motion in macaque middle temporal and medial superior temporal visual cortical areas. J. Neurosci. 19, 7591–7602 (1999).
Cook, E.P. & Maunsell, J.H. Attentional modulation of behavioral performance and neuronal responses in middle temporal and ventral intraparietal areas of macaque monkey. J. Neurosci. 22, 1994–2004 (2002).
Battelli, L. et al. Unilateral right parietal damage leads to bilateral deficit for high-level motion. Neuron 20, 985–995 (2001).
Shadlen, M.N. & Newsome, W.T. Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey. J. Neurophysiol. 86, 1916–1936 (2001).
Coe, B., Tomihara, K., Matsuzawa, M. & Hikosaka, O. Visual and anticipatory bias in three cortical eye fields of the monkey during an adaptive decision-making task. J. Neurosci. 22, 5081–5090 (2002).
Basso, M.A. & Wurtz, R.H. Modulation of neuronal activity in superior colliculus by changes in target probability. J. Neurosci. 18, 7519–7534 (1998).
Dorris, M.C., Paré, M. & Munoz, D.P. Immediate neural plasticity shapes motor performance. J. Neurosci. 20, RC52, 1–5 (2000).
Acknowledgements
We thank R. Born and C. Pack for comments on the manuscript, D. Bradley for general advice on experimental design and A. Parker for advice on eye-movement analysis. Supported by National Eye Institute EY12106 and the McKnight Endowment Fund for Neuroscience.
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Williams, Z., Elfar, J., Eskandar, E. et al. Parietal activity and the perceived direction of ambiguous apparent motion. Nat Neurosci 6, 616–623 (2003). https://doi.org/10.1038/nn1055
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DOI: https://doi.org/10.1038/nn1055
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