Neurofibrillary tangles, composed of tau protein, are a central feature of Alzheimer disease. A new paper challenges the idea that these tau inclusions alone cause disease by showing that they can be dissociated from memory impairment and neuronal loss.
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Ann Thomson
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Trojanowski, J., Lee, VY. Pathological tau: a loss of normal function or a gain in toxicity?. Nat Neurosci 8, 1136–1137 (2005). https://doi.org/10.1038/nn0905-1136
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DOI: https://doi.org/10.1038/nn0905-1136
