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Rosacea: skin innate immunity gone awry?

Nature Medicine volume 13, pages 904–906 (2007)Cite this article

Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975–981).

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Figure 1: Rosacea and proteolytic processing of cathelicidin peptides.

Katie Ris-Vicari

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Authors and Affiliations

  1. Charles L. Bevins is in the Departments of Microbiology and Immunology, School of Medicine, and Graduate Group in Immunology, University of California, Davis, California 95616, USA. clbevins@ucdavis.edu,

    Charles L Bevins

  2. Fu-Tong Liu is in the Department of Dermatology, School of Medicine, and Graduate Group in Immunology, University of California, Sacramento, California 95817, USA. fliu@ucdavis.edu,

    Fu-Tong Liu

Authors
  1. Charles L Bevins
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  2. Fu-Tong Liu
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The authors declare no competing financial interests.

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Bevins, C., Liu, FT. Rosacea: skin innate immunity gone awry?. Nat Med 13, 904–906 (2007). https://doi.org/10.1038/nm0807-904

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