Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RBP4, an unexpected adipokine

Nature Medicine volume 12, pages 30–31 (2006)Cite this article

Defects in the ability of fat cells to transport glucose are linked to insulin resistance in muscle and liver. Retinol binding protein 4 (RBP4) now comes to the fore as a new adipokine, linking glucose uptake in adipocytes with systemic insulin sensitivity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Expression of GLUT4 in adipose tissue regulates glucose metabolism in skeletal muscle and liver through RBP4.

Simon Fenwick

References

  1. Shepherd, P.R. & Kahn, B.B. N. Engl. J. Med. 341, 248–257 (1999).

    Article  CAS  Google Scholar 

  2. Shepherd, P.R. et al. J. Biol. Chem. 268, 22243–22246 (1993).

    CAS  Google Scholar 

  3. Abel, E.D. et al. Nature 409, 729–733 (2001).

    Article  CAS  Google Scholar 

  4. Zisman, A. et al. Nat. Med. 6, 924–928 (2000).

    Article  CAS  Google Scholar 

  5. Yang, Q. et al. Nature 436, 356–362 (2005).

    Article  CAS  Google Scholar 

  6. Blüher, M. et al. Dev. Cell 3, 25–38 (2002).

    Article  Google Scholar 

  7. Farnier, C. et al. Int. J. Obes. Relat. Metab. Disord. 27, 1178–1186 (2003).

    Article  CAS  Google Scholar 

  8. Furukawa, S. et al. J. Clin. Invest. 14, 1752–1761 (2004).

    Article  Google Scholar 

  9. Kershaw, E.E. & Flier, J.S. J. Clin. Endocrinol. Metab. 89, 2548–2556 (2004)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Diabetes, Department of Clinical Molecular Medicine, Digestive, and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshikazu Tamori, Hiroshi Sakaue & Masato Kasuga

Authors
  1. Yoshikazu Tamori
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Sakaue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masato Kasuga
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tamori, Y., Sakaue, H. & Kasuga, M. RBP4, an unexpected adipokine. Nat Med 12, 30–31 (2006). https://doi.org/10.1038/nm0106-30

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0106-30

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing