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Antigen presentation to naive CD4 T cells in the lymph node

Nature Immunology volume 4, pages 733–739 (2003)Cite this article

Abstract

Although the presentation of peptide–major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.

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Figure 1: Location of DC subsets in the lymph node.
Figure 2: Localization of lymph node DCs, injected soluble antigen and collagen network in situ.

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Acknowledgements

We thank T. Leonard for help with the animation. Supported by grants from the National Institutes of Health and the Irvington Institute of Immunological Research.

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  1. Department of Microbiology and the Center for Immunology, University of Minnesota, MMC 334, 420 Delaware St. SE, Minneapolis, 55455, Minnesota, USA

    Andrea A Itano & Marc K Jenkins

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Itano, A., Jenkins, M. Antigen presentation to naive CD4 T cells in the lymph node. Nat Immunol 4, 733–739 (2003). https://doi.org/10.1038/ni957

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