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Lymphocytes, Jim Gowans and in vivo veritas

Jim Gowans opened a new era of immunology by combining physiological in vivo studies with prospective enrichment of small lymphocytes, validating the clonal selection theory, discovering lymphocyte homing and recirculation, and training others to follow.

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References

  1. Weissman, I.L. Immunol. Rev. 185, 159–174 (2002).

    Article  CAS  PubMed  Google Scholar 

  2. Burnet, F.M. The Clonal Selection Theory of Acquired Immunology (Cambridge University Press, London, 1959).

    Google Scholar 

  3. Mitchison, N.A. & Dube, O.L. J. Exp. Med. 102, 179 (1955).

    Article  PubMed Central  Google Scholar 

  4. Maximow, A. Folia Haematol. (Leipzig) 8, 125–141 (1909).

    Google Scholar 

  5. Gowans, J.L. Ann. NY Acad. Sci. 99, 432–455 (1962).

    Article  CAS  PubMed  Google Scholar 

  6. Gowans, J.L. J. Physiol. (Lond.) 146, 54–69 (1959).

    Article  CAS  Google Scholar 

  7. Gowans, J.L., McGregor, D.D., Cowen, D.M. & Ford, C.E. Nature 196, 651–655 (1962).

    Article  CAS  PubMed  Google Scholar 

  8. McGregor, D.D. & Gowans, J.L. J. Exp. Med. 117, 303–320 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gowans, J.L. & Knight, E.J. Proc. R. Soc. Lond. B 159, 257–282 (1964).

    Article  CAS  PubMed  Google Scholar 

  10. Marchesi, V.T. & Gowans, J.L. Proc. R. Soc. Lond. B 159, 283–290 (1964).

    Article  CAS  PubMed  Google Scholar 

  11. Ford, W.L. & Gowans, J.L. Proc. R. Soc. Lond. B 168, 244–262 (1967).

    Article  CAS  PubMed  Google Scholar 

  12. McGregor, D.D., McCullagh, P.J. & Gowans, J.L. Proc. R. Soc. Lond. B 168, 229–243 (1967).

    Article  CAS  PubMed  Google Scholar 

  13. Gowans, J.L. & Uhr, J.W. J. Exp. Med. 124, 1017–1030 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Rowley, D.A., Gowans, J.L., Ford, W.L., Atkins, R.C. & Smith, M.E. J. Exp. Med. 136, 499–513 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Ellis, S.T. & Gowans, J.L. Proc. R. Soc. Lond. B 183, 125–139 (1973).

    Article  CAS  PubMed  Google Scholar 

  16. Dutton, R.W. & Mishell, R.I. J. Exp. Med. 126, 443–454 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Taylor, R.B., Duffus, W.P.H., Raff, M.C. & dePetris, S. Nat. New Biol. 233, 225–229 (1971).

    Article  CAS  PubMed  Google Scholar 

  18. de Petris, S. & Raff, M.C. Eur. J. Immunol. 2, 523–535 (1972).

    Article  CAS  PubMed  Google Scholar 

  19. Weissman, I.L. J. Exp. Med. 126, 291–304 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Weissman, I.L. J. Exp. Med. 137, 504–510 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Butcher, E.C., Scollay, R.G. & Weissman, I.L. Eur. J. Immunol. 10, 556–561 (1980).

    Article  CAS  PubMed  Google Scholar 

  22. Gallatin, W.M., Weissman, I.L. & Butcher, E.C. Nature 304, 30–34 (1983).

    Article  CAS  PubMed  Google Scholar 

  23. Gallatin, M. et al. Cell 44, 673–680 (1986).

    Article  CAS  PubMed  Google Scholar 

  24. Siegelman, M., van de Rijn, M. & Weissman, I.L. Science 243, 1165–1172 (1989).

    Article  CAS  PubMed  Google Scholar 

  25. Holzmann, B., McIntyre, B.W. & Weissman, I.L. Cell 56, 37–46 (1989).

    Article  CAS  PubMed  Google Scholar 

  26. Parrott, D.M.V., DeSousa, M.A.B. & East, J. J. Exp. Med. 123, 191–204 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Gutman, G.A. & Weissman, I.L. Immunology 23, 465–479 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Weissman, I.L., Warnke, R., Butcher, E., Rouse, R. & Levy, R. Hum. Pathol. 9, 25–45 (1978).

    Article  CAS  PubMed  Google Scholar 

  29. Muller–Sieburg, C., Whitlock, C.A. & Weissman, I.L. Cell 44, 653–662 (1986).

    Article  PubMed  Google Scholar 

  30. Spangrude, G.J., Heimfeld, S. & Weissman, I.L. Science 241, 58–62 (1988).

    Article  CAS  PubMed  Google Scholar 

  31. Baum, C.M., Weissman, I.L., Tsukamoto, A.S., Buckle, A. & Peault, B. Proc. Natl. Acad. Sci. USA 89, 2804–2808 (1992).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Uchida, N. et al. Proc. Natl. Acad. Sci. USA 97, 14720–14725 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Sherwood, R.I. et al. Cell 119, 543–554 (2004).

    Article  CAS  PubMed  Google Scholar 

  34. Chan, C.K. et al. Nature 457, 490–494 (2009).

    Article  CAS  PubMed  Google Scholar 

  35. Miyamoto, T., Weissman, I.L. & Akashi, K. Proc. Natl. Acad. Sci. USA 97, 7521–7526 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Jamieson, C.H. et al. N. Engl. J. Med. 351, 657–667 (2004).

    Article  CAS  PubMed  Google Scholar 

  37. Passegue, E., Wagner, E.F. & Weissman, I.L. Cell 119, 431–443 (2004).

    Article  CAS  PubMed  Google Scholar 

  38. Jamieson, C.H. et al. Proc. Natl. Acad. Sci. USA 103, 6224–6229 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Prince, M.E. et al. Proc. Natl. Acad. Sci. USA 104, 973–978 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Majeti, R. et al. Proc. Natl. Acad. Sci. USA 106, 3396–3401 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Abrahamsson, A.E. et al. Proc. Natl. Acad. Sci. USA 106, 3925–3929 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Chan, K.S. et al. Proc. Natl. Acad. Sci. USA 106, 14016–14021 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Silverstein, A.M. Nat. Immunol. 2, 569–571 (2001).

    Article  CAS  PubMed  Google Scholar 

  44. Miller, J.F.A.P. Nat. Immunol. 2, 981–982 (2001).

    Article  CAS  PubMed  Google Scholar 

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I.W. owns Amgen stock and is a director and consultant for Stem Cells.

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Weissman, I. Lymphocytes, Jim Gowans and in vivo veritas. Nat Immunol 11, 1073–1075 (2010). https://doi.org/10.1038/ni1210-1073

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