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Alternative splicing and genome complexity

Nature Genetics volume 30, pages 29–30 (2002)Cite this article

Abstract

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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Figure 1: EST estimations of alternative splicing from different eurkaryotes.
Figure 2: Dependence of alternative splicing prediction on EST coverage.

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Authors and Affiliations

  1. Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125, Germany

    David Brett, Heike Pospisil, Jens Reich & Peer Bork

  2. European Molecular Biology Laboratory, Meyerhofstr. 1, Heidelberg, 69012, Germany

    Juan Valcárcel & Peer Bork

Authors
  1. David Brett
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  2. Heike Pospisil
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  3. Juan Valcárcel
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  4. Jens Reich
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  5. Peer Bork
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Brett, D., Pospisil, H., Valcárcel, J. et al. Alternative splicing and genome complexity. Nat Genet 30, 29–30 (2002). https://doi.org/10.1038/ng803

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