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Morphological Transformation of Human Astrocytes by Visna Virus with Complete Virus Production

Abstract

VISNA, a medium-sized RNA virus, is comparable in mode of maturation and a number of other properties with the RNA tumour viruses1,2. The virion also carries RNA-dependent DNA polymerase3–5. This enzyme was first discovered in RNA tumour viruses and thought perhaps unique to them6–9; but it was subsequently found in a very few other RNA viruses3,10, where tumorigenicity was not a known attribute. The question whether RNA-dependent DNA polymerase is a hallmark of malignancy therefore remains entirely open.

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MACINTYRE, E., WINTERSGILL, C. & THORMAR, H. Morphological Transformation of Human Astrocytes by Visna Virus with Complete Virus Production. Nature New Biology 237, 111–113 (1972). https://doi.org/10.1038/newbio237111a0

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