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Serum Binding of Calcium and the Red Cell Membrane in Cystic Fibrosis

Nature New Biology volume 235, pages 173–174 (1972)Cite this article

Abstract

THERE is evidence for a factor in the serum of cystic fibrosis patients which may play a role in the pathological manifestation of the genetic syndrome: serum of patients with cystic fibrosis alters the cilia movement of rabbit trachea in vitro1 and of oyster cilia2. This activity is apparently associated with the immunoglobulin fraction3,4. Balfe et al.5 reported a modification of sodium flux in red cells obtained from patients with cystic fibrosis. In the course of searching for evidence of interaction of serum with red cells in cystic fibrosis, we found that there is a substantial increase in serum calcium binding in patients with cystic fibrosis. This seems to be associated with a modified membrane protein electrophoretic pattern of cystic fibrosis red cells in specified experimental conditions.

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Authors and Affiliations

  1. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, 37203

    DAVID F. FITZPATRICK & ERWIN J. LANDON

  2. Department of Pediatrics, University of Kentucky, Lexington, Kentucky

    VERNON JAMES

Authors
  1. DAVID F. FITZPATRICK
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  2. ERWIN J. LANDON
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  3. VERNON JAMES
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FITZPATRICK, D., LANDON, E. & JAMES, V. Serum Binding of Calcium and the Red Cell Membrane in Cystic Fibrosis. Nature New Biology 235, 173–174 (1972). https://doi.org/10.1038/newbio235173a0

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  • DOI: https://doi.org/10.1038/newbio235173a0

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