Abstract
THE classical mammary tumour virus (MTV), also referred to as the Bittner virus, is transmitted in milk from mother to offspring. Studies1–4 of the fate and biological behaviour of MTV in BALB/cfC3H (C+) mice suggested to us that MTV goes through a cycle in the infected host. Milk-borne MTV (M-MTV), assumed to be B particles, is abundantly present in milk and mammary tissues of infected mice. It seems likely that, on entering the host, M-MTV first infects the erythropoietic cells; subsequently the virus is carried into the general circulation chiefly inside the reticulocyte fraction2 of red blood cells (RBC) in a form which we have called R-MTV4. We have also suggested4 that, in the MTV cycle, R-MTV functions in the infection of mammary tissues, which are the primary sites of production of M-MTV (or B particles). The latter form of the virus, in turn, is involved in the transport of the viral genome to the young through milk.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ritter, R. I., and Nandi, S., J. Nat. Cancer Inst., 40, 1313 (1968).
Ritter, R. I., and Nandi, S., Nature, 220, 403 (1968).
Nandi, S., Proc. US Nat. Acad. Sci., 58, 485 (1967).
Nandi, S., in Carcinogenesis: A Broad Critique, Proc. 20th Annual Symp. on Fundamental Cancer Res., 295 (Williams and Wilkins, Baltimore, 1967).
Lyons, M. J., and Moore, D. H., J. Nat. Cancer Inst., 35, 549 (1965).
Duesberg, P. H., and Blair, P. B., Proc. US Nat. Acad. Sci., 55, 1490 (1966).
Smith, G. H., Cancer Res., 27, 2179 (1967).
Sarkar, N. H., and Moore, D. H., J. Virol., 5, 230 (1970).
Duesberg, P. H., and Cardiff, R. D., Virology, 36, 696 (1968).
Baltimore, D., Nature, 226, 1209 (1970).
Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).
Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).
Scolnick, E. M., Aaronson, S. A., and Todaro, G. J., Proc. US Nat. Acad. Sci., 67, 1034 (1970).
Baluda, M. A., and Nayak, D. P., Proc. US Nat. Acad. Sci., 66, 329 (1970).
Prince, A. M., and Adams, W. R., Virology, 30, 151 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NANDI, S. Possibility of a DNA-containing Mammary Tumour Virus in Red Blood Cells of Mouse. Nature New Biology 230, 146–147 (1971). https://doi.org/10.1038/newbio230146a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio230146a0