Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.
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We would like to thank W. Kim for comments of the manuscript.
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Ramsey, M., Sharpless, N. ROS as a tumour suppressor?. Nat Cell Biol 8, 1213–1215 (2006). https://doi.org/10.1038/ncb1106-1213
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DOI: https://doi.org/10.1038/ncb1106-1213
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