Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Entosis: aneuploidy by invasion

Nature Cell Biology volume 13, pages 199–201 (2011)Cite this article

Subjects

Aneuploidy is one of the most prevalent phenotypes of human tumours, but the underlying cause of this phenomenon remains highly debated. Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown to perturb cytokinesis and induce the formation of aneuploid cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cytokinesis failure induced by entosis is a prelude to aneuploidy.

References

  1. Boveri, T. Zur Frage der Entstehung maligner tumoren (Jena, Gustav Fischer, 1914).

    Google Scholar 

  2. Overholtzer, M. et al. Cell 131, 966–979 (2007).

    Article  CAS  Google Scholar 

  3. Overholtzer, M. & Brugge, J. S. Nat. Rev. Mol. Cell Biol. 9, 796–809 (2008).

    Article  CAS  Google Scholar 

  4. Jensen, C. G., Jensen, L. C., Rieder, C. L., Cole, R. W. & Ault, J. G. Carcinogenesis 17, 2013–2021 (1996).

    Article  CAS  Google Scholar 

  5. Mazumdar, M. et al. Curr. Biol. 16, 1559–1564 (2006).

    Article  CAS  Google Scholar 

  6. Fujiwara, T. et al. Nature 437, 1043–1047 (2005).

    Article  CAS  Google Scholar 

  7. Shi, Q. & King, R. W. Nature 437, 1038–1042 (2005).

    Article  CAS  Google Scholar 

  8. Kracjovic, M. et al. Nat. Cell Biol. 13, 324–330 (2011).

    Article  Google Scholar 

  9. Ganem, N. J., Godinho, S. A. & Pellman, D. Nature 460, 278–282 (2009).

    Article  CAS  Google Scholar 

  10. Barr, F. A. & Gruneberg, U. Cell 131, 847–860 (2007).

    Article  CAS  Google Scholar 

  11. Ganem, N. J., Storchova, Z. & Pellman, D. Curr. Opin. Genet. Dev. 17, 157–162 (2007).

    Article  CAS  Google Scholar 

  12. Ricke, R. M., van Ree, J. H. & van Deursen, J. M. Trends Genet. 24, 457–466 (2008).

    Article  CAS  Google Scholar 

  13. Kops, G. J., Weaver, B. A. & Cleveland, D. W. Nat. Rev. Cancer 5, 773–785 (2005).

    Article  CAS  Google Scholar 

  14. Andreassen, P. R., Lohez, O. D., Lacroix, F. B. & Margolis, R. L. Mol. Biol. Cell 12, 1315–1328 (2001).

    Article  CAS  Google Scholar 

  15. Ganem, N. J. & Pellman, D. Cell 131, 437–440 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Aniek Janssen and René H. Medema are in the Department of Medical Oncology and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands. r.h.medema@umcutrecht.nl,

    Aniek Janssen & René H. Medema

Authors
  1. Aniek Janssen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. René H. Medema
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Janssen, A., Medema, R. Entosis: aneuploidy by invasion. Nat Cell Biol 13, 199–201 (2011). https://doi.org/10.1038/ncb0311-199

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb0311-199

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer