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Nuclear Hormone Receptors as Targets for New Drug Discovery

Bio/Technology volume 11, pages 1256–1261 (1993)Cite this article

Abstract

There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e. cAMP), and those that utilize internal, cytoplasmic or nuclear receptors (intracellular receptors) which upon activation by hormones interact directly with DNA and alter the genetic program of a cell. This review focuses on the mechanism of action of these intracellular receptors and discusses how such an understanding is expected to facilitate the discovery of new therapeutic agents.

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  1. Donald P. McDonnell: Corresponding author.

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  1. Department of Molecular Biology, Ligand Pharmaceuticals Inc., 11149 N. Torrey Pines Road, San Diego, CA, 92037

    Donald P. McDonnell, Elisabetta Vegeto & Martin A. G. Gleeson

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McDonnell, D., Vegeto, E. & Gleeson, M. Nuclear Hormone Receptors as Targets for New Drug Discovery. Nat Biotechnol 11, 1256–1261 (1993). https://doi.org/10.1038/nbt1193-1256

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