Inflammatory caspase proteins help to control pathogen replication by triggering pyroptotic cell death. It now emerges that cleavage of the caspase substrate gasdermin D is sufficient to induce pyroptosis. See Articles p.660 & p.666
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Broz, P. Caspase target drives pyroptosis. Nature 526, 642–643 (2015). https://doi.org/10.1038/nature15632
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DOI: https://doi.org/10.1038/nature15632
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