Elsevier

Mucosal Immunology

Volume 1, Issue 6, November 2008, Pages 460-469
Mucosal Immunology

Article
Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages

https://doi.org/10.1038/mi.2008.61Get rights and content
Under an Elsevier user license
open archive

Abstract

Mucosal immune responses must be tightly controlled, particularly in the intestine. As members of the mononuclear phagocyte family, dendritic cells (DCs) and macrophages are well represented in intestinal tissues and have developed unique functional niches. This review will focus on recent findings on antigen uptake and processing in the intestine and the role of DCs in the imprinting of homing receptors on T and B cells, the induction of immunoglobulin A B-cell responses, and the differentiation of regulatory T cells. It will also address the unique phenotype of intestinal macrophages and briefly what is known regarding the relationships between these cell types.

Cited by (0)

Supplementary information The online version of this article (doi:10.1038/mi.2008.61) contains supplementary material, which is available to authorized users.