Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Chiorazzi N, Rai KR, Ferrarini M . Chronic lymphocytic leukemia. N Engl J Med 2005; 352: 804–815.

    Article  CAS  PubMed  Google Scholar 

  2. Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S . From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37–50.

    Article  CAS  PubMed  Google Scholar 

  3. Caligaris-Cappio F, Ghia P . Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 2008; 26: 4497–4503.

    Article  CAS  PubMed  Google Scholar 

  4. Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N . CD38 and chronic lymphocytic leukemia: a decade later. Blood 2011; 118: 3470–3478.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Deaglio S, Aydin S, Grand MM, Vaisitti T, Bergui L, D'Arena G et al. CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med 2010; 16: 87–91.

    Article  CAS  PubMed  Google Scholar 

  6. Deaglio S, Vaisitti T, Zucchetto A, Gattei V, Malavasi F . CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells. Semin Cancer Biol 2010; 20: 416–423.

    Article  CAS  PubMed  Google Scholar 

  7. Vaisitti T, Aydin S, Rossi D, Cottino F, Bergui L, D'Arena G et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia 2010; 24: 958–969.

    Article  CAS  PubMed  Google Scholar 

  8. Zucchetto A, Vaisitti T, Benedetti D, Tissino E, Bertagnolo V, Rossi D et al. The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia 2012; 26: 1301–1312.

    Article  CAS  PubMed  Google Scholar 

  9. Jaksic O, Paro MM, Kardum Skelin I, Kusec R, Pejsa V, Jaksic B . CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow. Blood 2004; 103: 1968–1969.

    Article  CAS  PubMed  Google Scholar 

  10. Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007; 110: 3352–3359.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, Moreno C et al. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood 2009; 114: 4832–4842.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Redondo-Munoz J, Escobar-Diaz E, Samaniego R, Terol MJ, Garcia-Marco JA, Garcia-Pardo A . MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 2006; 108: 3143–3151.

    Article  CAS  PubMed  Google Scholar 

  13. Buggins AG, Levi A, Gohil S, Fishlock K, Patten PE, Calle Y et al. Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9. Br J Haematol 2011; 154: 216–222.

    Article  CAS  PubMed  Google Scholar 

  14. Caligaris-Cappio F, Bergui L, Tesio L, Corbascio G, Tousco F, Marchisio PC . Cytoskeleton organization is aberrantly rearranged in the cells of B chronic lymphocytic leukemia and hairy cell leukemia. Blood 1986; 67: 233–239.

    CAS  PubMed  Google Scholar 

  15. Deaglio S, Aydin S, Vaisitti T, Bergui L, Malavasi F . CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med 2008; 14: 210–218.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Katiuscia Gizzi for skillful technical assistance. This work was supported in part by the Associazione Italiana Ricerca Cancro (IG #8590), by the Italian Ministries of Health (Bando Giovani Ricercatori 2008) and Education (Bando FIRB Giovani 2008 and Bando PRIN 2009) and by the Human Genetics Foundation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S Deaglio.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vaisitti, T., Serra, S., Pepper, C. et al. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. Leukemia 27, 1177–1181 (2013). https://doi.org/10.1038/leu.2012.260

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2012.260

This article is cited by

Search

Quick links