This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Chiorazzi N, Rai KR, Ferrarini M . Chronic lymphocytic leukemia. N Engl J Med 2005; 352: 804–815.
Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S . From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37–50.
Caligaris-Cappio F, Ghia P . Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 2008; 26: 4497–4503.
Malavasi F, Deaglio S, Damle R, Cutrona G, Ferrarini M, Chiorazzi N . CD38 and chronic lymphocytic leukemia: a decade later. Blood 2011; 118: 3470–3478.
Deaglio S, Aydin S, Grand MM, Vaisitti T, Bergui L, D'Arena G et al. CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med 2010; 16: 87–91.
Deaglio S, Vaisitti T, Zucchetto A, Gattei V, Malavasi F . CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells. Semin Cancer Biol 2010; 20: 416–423.
Vaisitti T, Aydin S, Rossi D, Cottino F, Bergui L, D'Arena G et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia 2010; 24: 958–969.
Zucchetto A, Vaisitti T, Benedetti D, Tissino E, Bertagnolo V, Rossi D et al. The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells. Leukemia 2012; 26: 1301–1312.
Jaksic O, Paro MM, Kardum Skelin I, Kusec R, Pejsa V, Jaksic B . CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow. Blood 2004; 103: 1968–1969.
Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007; 110: 3352–3359.
Calissano C, Damle RN, Hayes G, Murphy EJ, Hellerstein MK, Moreno C et al. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood 2009; 114: 4832–4842.
Redondo-Munoz J, Escobar-Diaz E, Samaniego R, Terol MJ, Garcia-Marco JA, Garcia-Pardo A . MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood 2006; 108: 3143–3151.
Buggins AG, Levi A, Gohil S, Fishlock K, Patten PE, Calle Y et al. Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9. Br J Haematol 2011; 154: 216–222.
Caligaris-Cappio F, Bergui L, Tesio L, Corbascio G, Tousco F, Marchisio PC . Cytoskeleton organization is aberrantly rearranged in the cells of B chronic lymphocytic leukemia and hairy cell leukemia. Blood 1986; 67: 233–239.
Deaglio S, Aydin S, Vaisitti T, Bergui L, Malavasi F . CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med 2008; 14: 210–218.
Acknowledgements
We thank Katiuscia Gizzi for skillful technical assistance. This work was supported in part by the Associazione Italiana Ricerca Cancro (IG #8590), by the Italian Ministries of Health (Bando Giovani Ricercatori 2008) and Education (Bando FIRB Giovani 2008 and Bando PRIN 2009) and by the Human Genetics Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Rights and permissions
About this article
Cite this article
Vaisitti, T., Serra, S., Pepper, C. et al. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. Leukemia 27, 1177–1181 (2013). https://doi.org/10.1038/leu.2012.260
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2012.260