ArticleNeuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Neuropilins (NRP) are cell surface receptors for vascular endothelial growth factor (VEGF) and members of the class 3 semaphorin (SEMA3) family of guidance proteins. The role of NRP in neurons and endothelial cells has been investigated, but the expression and role of NRP in epithelial cells is not clear. This study examines the expression and localization of neuropilin 1 (NRP1) in squamous cell carcinomas (SCC). The expression of NRP1 is regulated in the skin and is selectively produced in differentiated epithelial cells. NRP1 may function as a reservoir to sequester VEGF ligand within the epithelial compartment, thereby modulating its bioactivity.
Supplementary information The online version of this article (doi:10.1038/labinvest.2014.66) contains supplementary material, which is available to authorized users.
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Shokoufeh Shahrabi-Farahani and Lili Wang: These authors contributed equally to this work.