Research ArticleTranscription factor Runx2 is a regulator of epithelial–mesenchymal transition and invasion in thyroid carcinomas
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Keywords
epithelial–mesenchymal transition
immunohistochemistry
real-time PCR
Runx2
thyroid carcinoma
Cited by (0)
Dong-Feng Niu and Tetsuo Kondo: The first two authors are co-first authors with equal contribution in this work.
The tumor-promoting properties of the transcription factor Runx2 are explored in thyroid carcinoma. Enhanced expression of Runx2 is functionally linked to tumor invasion and metastasis by the regulation of epithelial-mesenchymal transition-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors.
© 2012 United States & Canadian Academy of Pathology.