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Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats

International Journal of Impotence Research volume 24, pages 31–37 (2012)Cite this article

Abstract

Sustained hyperglycemia is considered as a major cause of sexual and erectile dysfunction in human population. Curculigo orchioides (CO) is considered as a sexual tonic in Ayurvedic system of medicine with potent antioxidant and adaptogenic properties. The aqueous extract of the herb was evaluated for its effectiveness against streptozotocin-induced hyperglycemic stress and subsequent sexual dysfunction due to hyperglycemia in male rats. Six groups with eight male rats in each group were used for this study and the study was carried out for 28 days. The body and organ weights of the animals were recorded. Behavioral analysis of rats was undertaken to observe the effect on mount, ejaculation and intromission (latencies and frequencies) and hesitation time. Blood glucose and serum testosterone levels were determined 28 days past treatment with CO at 100 and 200 mg kg−1 doses. Glibenclamide and sildenafil citrate were used as positive controls. This deleterious effect of sustained hyperglycemia and associated stress was prominently ameliorated in animals treated with aqueous extract of CO. CO treatment was helpful in ameliorating the damage caused by sustained hyperglycemia evidenced in the principle parameters viz. male sexual behavior, sperm count, penile erection index and seminal fructose content Antioxidant and anabolic activities of the extract under investigation could be a major attribute in preserving the sexual functions in hyperglycemic male rats. The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency.

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References

  1. Buranakitjaroen P, Mangklabruks A, Leungwattanakij S, Ngaothamatasn W, Malhotra C, Chee C et al. Efficacy and safety of sildenafil in Asian males with erectile dysfunction and cardiovascular risk. J Med Assoc Thai 2007; 90: 1100–1108.

    PubMed  Google Scholar 

  2. Shiri R, Hassani KF, Ansari M . Association between opium abuse and comorbidity in diabetic men. Am J Addict 2006; 15: 468–472.

    Article  Google Scholar 

  3. Shabsigh R, Shah M, Sand M . Erectile dysfunction and men's health: developing a comorbidity risk calculator. J Sex Med 2008; 5: 1237–1243.

    Article  Google Scholar 

  4. Thakur M, Bhargava S, Dixit VK . Immunomodulatory activity of Chlorophytum borivilianum Sant. F. Evid Based Complement Alternat Med 2007; 4: 419–423.

    Article  Google Scholar 

  5. Thakur M, Chauhan NS, Bhargava S, Dixit VK . A comparative study on aphrodisiac activity of some ayurvedic herbs in male albino rats. Arch Sex Behav 2009; 38: 1009–1015.

    Article  Google Scholar 

  6. Chauhan NS, Rao Ch V, Dixit VK . Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats. Fitoterapia 2007; 78: 530–534.

    Article  CAS  Google Scholar 

  7. Lakshmi V, Pandey K, Puri A, Saxena RP, Saxena KC . Immunostimulant principles from Curculigo orchioides. J Ethnopharmacol 2003; 89: 181–184.

    Article  CAS  Google Scholar 

  8. Bafna AR, Mishra SH . Immunostimulatory effect of methanol extract of Curculigo orchioides on immunosuppressed mice. J Ethnopharmacol 2006; 104: 1–4.

    Article  CAS  Google Scholar 

  9. Gupta M, Achari B, Pal BC . Glucosides from Curculigo orchioides. Phytochemistry 2005; 66: 659–663.

    Article  CAS  Google Scholar 

  10. Venukumar MS, Latha MS . Antioxidant activity of Curculigo orchioides in carbon tetrachloride-induced hepatopathy in rats. Ind J Clin Biochem 2002; 17: 1–8.

    Article  Google Scholar 

  11. Amaral S, Oliveira PJ, Ramalho-Santos J . Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev 2008; 4: 46–54.

    Article  CAS  Google Scholar 

  12. Scarano WR, Messias AG, Oliva SU, Klinefelter GR, Kempinas WG . Sexual behaviour, sperm quantity and quality after short-term streptozotocin-induced hyperglycaemia in rats. Int J Androl 2006; 29: 482–488.

    Article  CAS  Google Scholar 

  13. Agmo A . Copulation-contingent aversive conditioning and sexual incentive motivation in male rats: evidence for a two-stage process of sexual behavior. Physiol Behav 2002; 77: 425–435.

    Article  CAS  Google Scholar 

  14. Ottoni EB . EthoLog 2.2: a tool for the transcription and timing of behavior observation sessions. Behav Res Methods Instrum Comput 2000; 32: 446–449.

    Article  CAS  Google Scholar 

  15. Shrikumar S, Athem M, Sukumar M, Ravi TK . A HPTLC method for standardization of Curculigo orchioides rhizomes and its marketed formulation using gallic acid as standard. Ind J Pharm Sci 2005; 67: 721–724.

    CAS  Google Scholar 

  16. Ang HH, Ngai TH . Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundam Clin Pharmacol 2001; 15: 265–268.

    Article  CAS  Google Scholar 

  17. Bonilla-Jaime H, Vázquez-Palacios G, Arteaga-Silva M, Retana-Márquez S . Hormonal responses to different sexually related conditions in male rats. Horm Behav 2006; 49: 376–382.

    Article  CAS  Google Scholar 

  18. Thakur M, Dixit VK . Effect of Chlorophytum borivilianum on androgenic and sexual behaviour of male rats. Indian Drugs 2006; 43: 300–306.

    Google Scholar 

  19. Islam MW, Tariq M, Ageel AM, al-Said MS, al-Yhya AM . Effect of Salvia haematodes on sexual behaviour of male rats. J Ethnopharmacol 1991; 33: 67–72.

    Article  CAS  Google Scholar 

  20. Thakur M, Loeppert R, Praznik W, Dixit VK . Effect of some ayurvedic vajikaran rasayana herbs on heat induced testicular damage in male albino rats. J Compl Int Med 2008; 5: 1–8.

    Google Scholar 

  21. Thakur M, Bhargava S, Dixit VK . Effect of Asparagus racemosus on sexual dysfunction in hyperglycemic male rats. Pharma Biol 2009; 47: 390–395.

    Article  Google Scholar 

  22. Qian SZ, Zhong CQ, Xu Y . Effect of Tripterigium wilfordii Hook. f. on the fertility of rats. Contraception 1986; 33: 105–110.

    Article  CAS  Google Scholar 

  23. Almeida SA, Petenusci SO, Anselmo-Franci JA, Rosa-e-Silva AA, Lamano-Carvalho TL . Decreased spermatogenic and androgenic testicular functions in adult rats submitted to immobilization-induced stress from prepuberty. Braz J Med Biol Res 1998; 31: 1443–1448.

    Article  CAS  Google Scholar 

  24. Mulat B, Arbel Y, Mashav N, Saar N, Steinvil A, Heruti R et al. Depressive symptoms and erectile dysfunction in men with coronary artery disease. Urology 2010; 75: 104–107.

    Article  Google Scholar 

  25. Amaral S, Oliveira PJ, Ramalho-Santos J . Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev 2008; 4: 46–54.

    Article  CAS  Google Scholar 

  26. Steger RW . Testosterone replacement fails to reverse the adverse effects of streptozotocin-induced diabetes on sexual behavior in the male rat. Pharmacol Biochem Behav 1990; 35: 577–582.

    Article  CAS  Google Scholar 

  27. Steger RW, Amador A, Lam E, Rathert J, Weis J, Smith MS . Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology 1989; 124: 1737–1743.

    Article  CAS  Google Scholar 

  28. Hassan AA, Hassouna MM, Taketo T, Gagnon C, Elhilali MM . The effect of diabetes on sexual behavior and reproductive tract function in male rats. J Urol 1993; 149: 148–154.

    Article  CAS  Google Scholar 

  29. Miller LG . Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med 1998; 158: 2200–2211.

    Article  CAS  Google Scholar 

  30. Madhavan V, Joshi R, Murli A, Yoganarsimhan SN . Antidiabetic activity of Curculigo orchioides root tuber. Pharmaceutical Biology 2007; 45: 18–21.

    Article  CAS  Google Scholar 

  31. Wu Q, Fu DX, Hou AJ, Lei GQ, Liu ZJ, Chen JK et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo) 2005; 53: 1065–1067.

    Article  CAS  Google Scholar 

  32. Chauhan NS, Sharma V, Thakur M, Dixit VK . Curculigo orchioides: the black gold with numerous health benefits. Zhong Xi Yi Jie He Xue Bao 2010; 8: 613–623.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Central institute for Laboratory Medicine, Charite, Campus Benjamin Franklin, Hindenburgdamm, Berlin, Germany

    M Thakur

  2. Department of Pharmaceutical Sciences, Dr H S Gour University, Sagar,, MP, India

    M Thakur, N S Chauhan, V Sharma, V K Dixit & S Bhargava

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  1. M Thakur
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  2. N S Chauhan
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  4. V K Dixit
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  5. S Bhargava
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Correspondence to M Thakur.

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Thakur, M., Chauhan, N., Sharma, V. et al. Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. Int J Impot Res 24, 31–37 (2012). https://doi.org/10.1038/ijir.2011.43

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