Abstract
This study examined the association between magnesium intake and type II diabetes risk among Japanese adults. Participants were 25 872 men and 33 919 women aged 45–75 years who had no history of diabetes. Magnesium intake was ascertained using a 147-item food frequency questionnaire. Odds ratio of self-reported physician-diagnosed type II diabetes over 5 years was estimated using logistic regression analysis. A total of 1114 new cases of type II diabetes were self-reported. Magnesium intake was not significantly associated with type II diabetes in either men or women. The multivariable-adjusted odds ratios (95% confidence intervals) of type II diabetes for the highest versus lowest quintile of magnesium intake were 0.86 (0.63–1.16) and 0.92 (0.66–1.28) for men and women, respectively. Although a small effect cannot be excluded in men, magnesium intake may not be appreciably associated with risk of type II diabetes for Japanese adults.
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Acknowledgements
We thank Dr Yumi Matsushita (International Medical Center of Japan) and Dr Masayuki Kato (Japan Foundation for the Promotion of International Medical Research Cooperation) for the helpful discussions. This work was supported by Grants-in-Aid for Cancer Research (19shi-2) and a Health Sciences Research Grant (Research on Comprehensive Research on Cardiovascular Diseases H19-016) from the Ministry of Health, Labour and Welfare of Japan.
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Appendix
Appendix
Study group members
Members of the Japan Public Health Center-based Prospective Study (JPHC Study, principal investigator: S Tsugane) Group are: S Tsugane, M Inoue, T Sobue and T Hanaoka (National Cancer Center, Tokyo, Japan); J Ogata, S Baba, T Mannami, A Okayama and Y Kokubo (National Cardiovascular Center, Osaka, Japan); K Miyakawa, F Saito, A Koizumi, Y Sano, I Hashimoto, T Ikuta and Y Tanaba (Iwate Prefectural Ninohe Public Health Center, Iwate, Japan); Y Miyajima, N Suzuki, S Nagasawa, Y Furusugi and N Nagai (Akita Prefectural Yokote Public Health Center, Akita, Japan); H Sanada, Y Hatayama, F Kobayashi, H Uchino, Y Shirai, T Kondo, R Sasaki, Y Watanabe, Y Miyagawa and Y Kobayashi (Nagano Prefectural Saku Public Health Center, Nagano, Japan); Y Kishimoto, E Takara, T Fukuyama, M Kinjo, M Irei and H Sakiyama (Okinawa Prefectural Chubu Public Health Center, Okinawa, Japan); K Imoto, H Yazawa, T Seo, A Seiko, F Ito, F Shoji and R Saito (Katsushika Public Health Center, Tokyo, Japan); A Murata, K Minato, K Motegi and T Fujieda (Ibaraki Prefectural Mito Public Health Center, Ibaraki, Japan); K Matsui, T Abe, M Katagiri and M Suzuki (Niigata Prefectural Kashiwazaki and Nagaoka Public Health Center, Niigata, Japan); M Doi, A Terao, Y Ishikawa and T Tagami (Kochi Prefectural Chuo-higashi Public Health Center, Kochi, Japan); H Sueta, H Doi, M Urata, N Okamoto and F Ide (Nagasaki Prefectural Kamigoto Public Health Center, Nagasaki, Japan); H Sakiyama, N Onga, H Takaesu and M Uehara (Okinawa Prefectural Miyako Public Health Center, Okinawa, Japan); F Horii, I Asano, H Yamaguchi, K Aoki, S Maruyama, M Ichii and M Takano (Osaka Prefectural Suita Public Health Center, Osaka, Japan); Y Tsubono (Tohoku University, Miyagi, Japan); K Suzuki (Research Institute for Brain and Blood Vessels Akita, Akita, Japan); Y Honda, K Yamagishi, S Sakurai and N Tsuchiya (Tsukuba University, Ibaraki, Japan); M Kabuto (National Institute for Environmental Studies, Ibaraki, Japan); M Yamaguchi, Y Matsumura, S Sasaki and S Watanabe (National Institute of Health and Nutrition, Tokyo, Japan); M Akabane (Tokyo University of Agriculture, Tokyo, Japan); T Kadowaki (Tokyo University, Tokyo, Japan); M Noda and T Mizoue (International Medical Center of Japan, Tokyo, Japan); Y Kawaguchi (Tokyo Medical and Dental University, Tokyo, Japan); Y Takashima and M Yoshida (Kyorin University, Tokyo, Japan); K Nakamura (Niigata University, Niigata, Japan); S Matsushima and S Natsukawa (Saku General Hospital, Nagano, Japan); H Shimizu (Sakihae Institute, Gifu, Japan); H Sugimura (Hamamatsu University, Shizuoka, Japan); S Tominaga (Aichi Cancer Center Research Institute, Aichi, Japan); H Iso (Osaka University, Osaka, Japan); M Iida, W Ajiki and A Ioka (Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan); S Sato (Chiba Prefectural Institute of Public Health, Chiba, Japan); E Maruyama (Kobe University, Hyogo, Japan); M Konishi, K Okada and I Saito (Ehime University, Ehime, Japan); N Yasuda (Kochi University, Kochi, Japan) and S Kono (Kyushu University, Fukuoka, Japan).
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Nanri, A., Mizoue, T., Noda, M. et al. Magnesium intake and type II diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study. Eur J Clin Nutr 64, 1244–1247 (2010). https://doi.org/10.1038/ejcn.2010.138
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DOI: https://doi.org/10.1038/ejcn.2010.138
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