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References
Gajewski TF, Schreiber H, Fu YX . Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013; 14: 1014–1022.
Wynn TA, Chawla A, Pollard JW . Macrophage biology in development, homeostasis and disease. Nature 2013; 496: 445–455.
Qian BZ, Pollard JW . Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141: 39–51.
Grivennikov SI, Greten FR, Karin M . Immunity, inflammation, and cancer. Cell 2010; 140: 883–899.
Noy R, Pollard JW . Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014; 41: 49–61.
Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K et al. The cellular and molecular origin of tumor-associated macrophages. Science 2014; 344: 921–925.
Perdiguero EG, Geissmann F . Cancer immunology. Identifying the infiltrators. Science 2014; 344: 801–802.
Palaga T, Ratanabunyong S, Pattarakankul T, Sangphech N, Wongchana W, Hadae Y et al. Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages. Cell Mol Immunol 2013; 10: 444–452.
Wang YC, He F, Feng F, Liu XW, Dong GY, Qin HY et al. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Res 2010; 70: 4840–4849.
Rosas M, Davies LC, Giles PJ, Liao CT, Kharfan B, Stone TC et al. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 2014; 344: 645–648.
Okabe Y, Medzhitov R . Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 2014; 157: 832–844.
Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 2014; 15: 423–430.
van Dyken SJ, Locksley RM . Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol 2013; 31: 317–343.
Alderton GK . Tumour immunology: turning macrophages on, off and on again. Nat Rev Immunol 2014; 14: 136–137.
Wu C, Zhang Y, Jiang Y, Wang Q, Long Y, Wang C et al. Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells. Cell Mol Immunol 2013; 10: 393–402.
Han Y, Chen Z, Yang Y, Jiang Z, Gu Y, Liu Y et al. Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma. Hepatology 2014; 59: 567–579.
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Liu, Y., Cao, X. The origin and function of tumor-associated macrophages. Cell Mol Immunol 12, 1–4 (2015). https://doi.org/10.1038/cmi.2014.83
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DOI: https://doi.org/10.1038/cmi.2014.83
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