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MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

Cellular & Molecular Immunology volume 8, pages 380–387 (2011)Cite this article

Abstract

MicroRNAs (miRNAs) are an abundant class of evolutionarily conserved, small, non-coding RNAs that post-transcriptionally regulate expression of their target genes. Emerging evidence indicates that miRNAs are important regulators that control the development, differentiation and function of different immune cells. Both CD4+CD25+Foxp3+ regulatory T (Treg) cells and invariant natural killer T (iNKT) cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and immunity. Here, we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

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Acknowledgements

This work was support in part by grants from the Juvenile Diabetes Research Foundation International and the Henry Ford Immunology Program startup.

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  1. Li Zhou and Jang-June Park: These authors contributed equally to this work.

Authors and Affiliations

  1. Henry Ford Immunology Program, Henry Ford Health System, Detroit, MI, USA

    Li Zhou, Jang-June Park, Quanhui Zheng & Qingsheng Mi

  2. Department of Dermatology, Henry Ford Health System, Detroit, MI, USA

    Li Zhou, Jang-June Park, Quanhui Zheng & Qingsheng Mi

  3. Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA

    Li Zhou & Qingsheng Mi

  4. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USA

    Zheng Dong

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Correspondence to Qingsheng Mi.

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Zhou, L., Park, JJ., Zheng, Q. et al. MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function. Cell Mol Immunol 8, 380–387 (2011). https://doi.org/10.1038/cmi.2011.27

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